Starting out in Edo, as Kyoshiro travels west toward Kyoto, he encounters some of the most dangerous obstacles in his career. Signs that the Tokugawa shogunate was vulnerable began to appear during the reign of 12th Shogun Ieyoshi. The Satsuma and the 13 Western non-Tokugawa lords began to act in suspicious ways. Minister Takebe, under orders from shogunate councilor Mizuno, attempted to quash this unrest. Nemuri Kyoshiro, a loner headed west, unwittingly becomes involved in the struggle.